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Members of the McMaster Ancient DNA Centre are active in different research projects.

Single nucleotide polymorphism (SNP) discovery in mammals: a targeted-gene approach

Here we describe the use of 'CATS' (or 'EPIC') primers for the detection of novel SNPs in non-model mammals. We observed that PCR success was highest in samples closely related to model organisms for which primers were initially designed, but due to the large number of CATS-like primers this approach may yield sufficient SNP data for conservation genetic studies in nonmodel organisms.

Jun 01, 2004

Characterization of 15 single nucleotide polymorphism markers for chimpanzees (Pan troglodytes)

Here we report 15 new single nucleotide polymorphism markers for the the threatened Chipanzee that span both Y chromosome and autosomal regions of the genome.

Apr 07, 2004

Isolation of nucleic acids and cultures from fossil ice and permafrost

A review of recent claims about viable cells and microbial nucleic acids obtained from ice and permafrost hundreds to millions of years old. We also outline a set of precautions and controls to help ensure authenticity of future studies.

Mar 18, 2004

Molecular evidence of tuberculosis induced hypertophic osteopathy in a 16th-century Iroquoian dog

Here we report on the oldest known case of TB to be discovered in domestic dogs and highlight their role as potential reservoirs of TB in the Americas.

Jan 01, 2004

Unreliable mtDNA data due to nuclear insertions: a cautionary tale from analysis of humans and other great apes

An analysis on the possible pitfalls 'numts' represent to mitochondrial DNA barcode data. We show that gorillas are particularly notable for possessing a variety of numt sequences bearing high similarity to authentic mtDNA.

Oct 21, 2003

Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees

Here we report a cross-species comparison of 10 X-chromosomal genes known to cause mental retardation in humans. Overall nucleotide diversity in these genes is lower both within and between species, suggesting a high level of purifying selection.

Aug 01, 2003

The Genetic Secrets Some Fossils Hold

Here we summarize screening approaches that can identify well-preserved specimens for ancient DNA analysis.

Jul 01, 2003

Nuclear Gene Sequences from a Late Pleistocene Sloth Coprolite

Here we show that nuclear DNA can be recovered from non-permafrost remains, but amplifying one multicopy and three single-copy nuclear gene fragments from a coprolite stemming from the extinct Shasta ground sloth. Nuclear sequences such can open up many novel opportunities such as finer resolution in phylogenies and the characterization of genes behind individual traits.

Jul 01, 2003

The top 10 list: criteria of authenticity for DNA from ancient and forensic samples

A summary of 10 criteria to ensure replication and authentication of ancient DNA recovered from ancient and forensic samples.

Jan 01, 2003